Gating Input to Visual Cortex by Feedback to LGN
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Abstract
Anatomical studies have documented massive back-projections from higher to lower visual cortices and to the lateral geniculate nucleus (LGN). The large number of synapses from these sources suggest that they should have a profound influence on the information carried by feed-forward inputs to these cells. However, the functional role of these connections is unclear. In order to explore the role of the feedback connections, we have recorded spike trains from electrodes placed in LGN in the macaque monkey under sufenta anesthesia, and have compared LGN cells' activity with and without suppression by cooling of feedback from primary visual cortex (V1). Normally, magno and parvo LGN cells show a wide range over which their responses are proportional to stimulus contrast. Inactivation of V1 feedback causes LGN cells to become more nonlinear and less sensitive to high contrast than during normal conditions. Responses during V1 inactivation have a similar shape to those of retinal ganglion cells. We have also tested the properties of the so-called extended surround as they relate to cortical activity and to influences on responses to LGN stimulation. A model of this data suggests an interpretation in terms of two fnuctional components of feedback: a contrast-dependent component which dominates at high input contrast, and a constant baseline level of inhibitory feedback. We also show that the influence of the extended surround on the classical center mechanism is more complicated than a simple integration model.
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Copyright 1998 Boston University. Permission to copy without fee all or part of this material is granted provided that: 1. The copies are not made or distributed for direct commercial advantage; 2. the report title, author, document number, and release date appear, and notice is given that copying is by permission of BOSTON UNIVERSITY TRUSTEES. To copy otherwise, or to republish, requires a fee and / or special permission.