Role of apoptosis in inflammatory processes: involvement of secreted frizzled-related protein 1 (SFRP1)
Date
2007
DOI
Authors
Li, Chung-Hsing
Version
OA Version
Citation
Abstract
Porphyromonas gingivalis (P. gingivalis) is implicated as a major pathogen in
periodontitis, a common infectious disease characterized by inflammation and destruction
of periodontal tissues. Wound healing is a complex cascade of events which diminishes
the size of the wound and reestablishes tissue integrity through three overlapping phases:
inflammation, proliferation, and maturation and remodeling. The inflammatory phase is
an essential phase of wound healing . Apoptosis, a mechanism of programmed cell death,
is critically important in many biological processes for the maintenance of tissue integrity
and homeostasis. S~creted frizzled-related protein 1 (SFRP 1) modulates apoptosis in
different cell types. On the basis of this evidence, we hypothesize that SFRPl plays an
important role in the regulation of inflammation in periodontitis and wound healing. The
aims in this study were (1) to evaluate the role of SFRPl in vivo in a mouse model of
periodontitis and (2) to investigate the role of SFRP 1 in vivo in a mouse model of wound
healing. [TRUNCATED]
Description
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.
Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2007 (Periodontology and Oral Biology).
Includes bibliography: (leaves 149-177).
Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2007 (Periodontology and Oral Biology).
Includes bibliography: (leaves 149-177).
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.