Orthotopic Skin Grafting in Albino and Agouti Hamsters
OA Version
Citation
Abstract
An investigation of first-set and second-set skin homografts in hamsters has been made in an attempt to characterize agouti
and albino hamsters (Mesocricetus auratus) with respect to their
genetic homogeneity. This work represents the first reported experimental
investigation of skin homografting in hamsters.
Attempts to characterize animals with regard to their genetic
similarity or dissimilarity by homografting skin are based on the welldocumented
observations that homografts fail experimentally unless made
between members of highly inbred strains, or succeed clinically ooly
when donor and host are identical twins. The most notable exception to
this formulation is the recent communication by Eichwald and Silmser
(19.55) that even within inbred strains of mice, homografts of sldn from
males to females failed , due probably to the Y-linkage of a histocompatibility
locus (Hauschka, 1955; Snell, 1956). Snell points out
that the fineness of the homograft response to skin, i.e. the complete
dependence of successful grafting on genetic identity, may be used more
profitably than tumor transplantation tests to explore the "weaker"
histocompatibility loci.[Truncated]
Description
Thesis (Ph.D)--Boston University
License
Based on investigation of the BU Libraries' staff, this work is free of known copyright restrictions.