Tang, JianboErdener, Sefik EvrenLi, BaoqiangFu, BuyinSakadzic, SavaCarp, Stefan A.Lee, JonghwanBoas, David A.Luo, Q.Ding, J.2019-09-042019-09-042018-01-01Jianbo Tang, Sefik Evren Erdener, Baoqiang Li, Buyin Fu, Sava Sakadzic, Stefan A. Carp, Jonghwan Lee, David A. Boas, "Measurement of shearinduced diffusion of red blood cells using dynamic light scattering-optical coherence tomography," Proc. SPIE 10481, Neural Imaging and Sensing 2018, 104811N (12 February 2018); https://doi.org/10.1117/12.22903450277-786X1996-756Xhttps://hdl.handle.net/2144/37657Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements indicate a blunted laminar flow profile, and the degree of blunting decreases with increasing vessel diameter. The measured shear-induced diffusion coefficient was proportional to the flow shear rate with a magnitude of ~ 0.1 to 0.5 × 10-6 mm2 . These results provide important experimental support for the recent theoretical explanation for why DCS is dominantly sensitive to RBC diffusive motion.© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.Life Sciences & BiomedicineNeuroimagingOpticsRadiology, nuclear medicine & medical imagingNeurosciences & neurologyBlood flow and radial profileShear-induced diffusion of RBCDynamic light scattering optical coherence tomographyConference materials10.1117/12.22903450000-0002-6709-7711 (Boas, David A)415944