Wang, WenyuCencic, ReginaWhitesell, LukePelletier, JerryPorco, John A.2018-01-302018-01-302016-08-16Wenyu Wang, Regina Cencic, Luke Whitesell, Jerry Pelletier, John A Porco. 2016. "Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.." Chemistry, Volume 22, Issue 34, pp. 12006 - 12010.1521-3765https://hdl.handle.net/2144/26487Synthesis of aza-rocaglates, nitrogen-containing analogues of the rocaglate natural products, is reported. The route features ESIPT-mediated (3+2) photocycloaddition of 1-alkyl-2-aryl-3-hydroxyquinolinones with the dipolarophile methyl cinnamate. A continuous photoflow reactor was utilized for photocycloadditions. An array of compounds bearing the hexahydrocyclopenta[b]indole core structure was synthesized and evaluated in translation inhibition assays.12006 - 12010Science & technologyPhysical sciencesChemistryESIPTFlow chemistryHeterocyclesPhotocycloadditionRocaglateEukaryotic translationSilvestrol analogsFlavaglinesChemical sciencesArticle10.1002/chem.201602953