Ribeiro, Sebastiao Alves2020-03-042020-03-0419761976(OCoLC)15971310b18436791https://hdl.handle.net/2144/39726PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (D.Sc.D.)--Boston University School of Graduate Dentistry (Oral biology and pathology), 1976.Includes bibliography.The question of a potential carcinogenic effect of isobutyl-2-cyanoacrylate, utilized as a hemostatic agent and tissue adhesive, was investigated in a long term study. Long-Evans hooded rats were subjected to experimental gingivectomy or extraction procedures; cyanoacrylate monomer was applied post-surgically as an aerosol or wet dressing with suitable controls employed. Two hundred and fifty animals, including controls, survived for examination sixteen to twenty-five months post-operatively, and form the basis for the hematologic and histopathologic observations. Blood studies were essentially normal compared to baseline data. There was no indication of a polymer residuum at superficial or deep application sites, nor was evidence found to substantiate a local neoplastic effect of applied isobutyl-2-cyanoacrylate.en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.CyanoacrylatesCarcinogensThesis/Dissertation