Nguyen, Christopher Hong2022-06-062022-06-0619961996(OCoLC)38736053b21881121https://hdl.handle.net/2144/44633PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 1996 (Orthodontics).Includes bibliographical references (leaves 79-90).Monocyte chemotactic protein (MCP-1) is a cytokine selectively chemotactic for monocytes/macrophages and is an important determinant of macrophages in neoplasms. [73,74] One source of the MCP-1 is the tumor cell. For example, tumor cells including gliomas [79], sarcomas [88], and myelomonocytic cells [81] were found to release tumor-derived chemotactic factor (TDCF) for monocyte/macrophage recruitment. The tumor-derived chemotactic factor was molecularly identified as MCP-1 or monocyte chemotactic and activating factor (MCAF). [81,85] The murine counterpart of the human MCP-1 is JE, which was identified in platelet-derived growth factor stimulated fibroblasts. [superscripts 82,83] MCP-1/JE is produced locally by various stimulated cell types such as monocyte/macrophages, fibroblasts, endothelial cells and malignant cells. [88] [TRUNCATED]en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Monocyte chemoattractant protein-1.Thesis/Dissertation