Mulcahy, Seann P.2012-01-032012-01-032012-01-03https://hdl.handle.net/2144/2684This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License: http://creativecommons.org/licenses/by-nc-sa/3.0/A convenient multi-week experiment that results in the formation of two new stereocenters starting from enantiopure norephedrine as the chiral auxiliary. This experiment uses a variety of purification techniques, including distillation, recrystallization, and column chromatography and is a useful extension of classroom topics. Students can be introduced to transition state modeling, COSY spectroscopy, Hammond postulate, and asymmetric induction.en-USAldol reactionChromatographyHammond postulateDistillationRecrystallizationAsymmetric inductionStereochemistryOther