Toro-Ramirez, Daniela2022-06-062022-06-0620112011(OCoLC)812028771b38960722https://hdl.handle.net/2144/44673PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2011 (Department of Restorative Sciences and Biomaterials).Includes bibliography: leaves 73-87.Objectives: The purpose of this study was to determine the effectiveness of several agents in preventing and/or treating demineralization (white spot lesions). Methods: Part I: Prevention of WSLs: Ten enamel discs were randomly allocated to each agent (60 samples in total): MiPaste Plus [R], Duraphat [R] varnish, Titanium tetrafluoride (4% TiF4) varnish, ACT [R], ProSeal, Control (no agent). After agent application, samples were immersed 96 hours in a demineralization solution (White’s 1987). Knoop microhardness testing (Buehler, Lake Bluff; IL) was used to determine enamel’s hardness (KHN). Part 2: Treatment of WSLs: Ten enamel discs were randomly allocated to each agent (40 samples in total): MiPaste Plus [R], Duraphat [R], TiF4, ACT [R], and Control. Samples were demineralized as above. Agents were then applied; samples were immersed in artificial saliva for seven days. KHN was determined at baseline, after demineralization, and after immersion in artificial saliva. [TRUNCATED]en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Tooth demineralizationThesis/Dissertation