Bright, Ian M.Meister, Miriam L.R.Cruzado, NathanaelTiganj, ZoranBuffalo, Elizabeth A.Howard, Marc W.2023-03-292023-03-292020-08-18I.M. Bright, M.L.R. Meister, N.A. Cruzado, Z. Tiganj, E.A. Buffalo, M.W. Howard. 2020. "A temporal record of the past with a spectrum of time constants in the monkey entorhinal cortex." Proceedings of the National Academy of Sciences of USA, Volume 117, Issue 33, pp.20274-20283. https://doi.org/10.1073/pnas.19171971170027-84241091-6490https://hdl.handle.net/2144/45976Episodic memory is believed to be intimately related to our experience of the passage of time. Indeed, neurons in the hippocampus and other brain regions critical to episodic memory code for the passage of time at a range of timescales. The origin of this temporal signal, however, remains unclear. Here, we examined temporal responses in the entorhinal cortex of macaque monkeys as they viewed complex images. Many neurons in the entorhinal cortex were responsive to image onset, showing large deviations from baseline firing shortly after image onset but relaxing back to baseline at different rates. This range of relaxation rates allowed for the time since image onset to be decoded on the scale of seconds. Further, these neurons carried information about image content, suggesting that neurons in the entorhinal cortex carry information about not only when an event took place but also, the identity of that event. Taken together, these findings suggest that the primate entorhinal cortex uses a spectrum of time constants to construct a temporal record of the past in support of episodic memory.p. 20274-20283Print-ElectronicenCopyright © 2020 the Author(s). This is an open access article and distributed under Creative Commons Attribution-NonCommercialNoDerivatives License 4.0 (CC BY-NC-ND)http://creativecommons.org/licenses/by-nc-nd/4.0/Laplace transformEntorhinal cortexMemoryTimeAnimalsBehavior, animalMacaca mulattaMaleMemory, episodicNeuronsTime factorsArticle2023-01-1910.1073/pnas.19171971170000-0002-4953-7779 (Bright, Ian M)0000-0002-4479-0126 (Meister, Miriam LR)0000-0002-6534-8118 (Cruzado, Nathanael A)0000-0002-1478-1237 (Howard, Marc W)564787