AlSharief, Mishali Saud2022-06-062022-06-0620142014(OCoLC)927175404(OCoLC)ocn927175404https://hdl.handle.net/2144/44527PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Dissertation (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Periodontology and Oral Biology).Includes bibliographic references: leaves 28-30.Introduction: Ever since the demand for orthodontic treatment has increased among adults, many new treatment modalities have been introduced in addition to conventional orthodontic treatment to accelerate and enhance the outcome of treatment. Although these surgical procedures may be technically different, most of them rely on the Regional Acceleratory Phenomenon (RAP) that follows bone injury. Piezocision {superscript TM] is a relatively new technique that also facilitates orthodontic treatment yet uses micro-incisions, thus being less invasive and more acceptable to patients and orthodontists. Aim: To investigate and describe histological changes associated with Piezocision [superscript TM] in conjunction with orthodontic therapy. Materials & Methods: A total of 59 young adult laboratory rats were used for the study. The effects of piezocision [superscript TM] (P), orthodontic tooth movement (TM), and a combination of both piezocision and tooth movement (P+TM) were studied using the maxillary first molar of the animals. The rats were then sacrificed at various time points, (0,1,3,7,14,28,42,56,days). The parameters studied were: tooth movement, catabolic activity (osteoclasts count), and the effect of the piezoelectric cut on bone demineralization in the buccolingual and mesiodistal dimensions. [TRUNCATED]en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Tooth movementRatsThesis/Dissertation