Hendricks, Audrey E.Zhu, YanyanDupuis, Josée2012-01-112012-01-1120092009-12-15Hendricks, Audrey E, Yanyan Zhu, Josée Dupuis. "Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic" BMC Proceedings 3(Suppl 7):S100. (2009)1753-6561https://hdl.handle.net/2144/3081Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.enCopyright 2009 Hendricks et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/2.0Article200179642795871