Roma, D. M.O'Flanagan, R. A.Ruckenstein, Andrei E.Sengupta, A. M.Mukhopadhyay, Ranjan2019-09-202019-09-202005-01-01D.M. Roma, R.A. O'Flanagan, A.E. Ruckenstein, A.M. Sengupta, R. Mukhopadhyay. 2005. "Optimal path to epigenetic switching." PHYSICAL REVIEW E, Volume 71, Issue 1, pp. ? - ? (5). https://doi.org/10.1103/PhysRevE.71.0119021063-651Xhttps://hdl.handle.net/2144/37971We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.5 p.en-USScience & technologyPhysical sciencesPhysics, fluids & plasmasPhysics, mathematicalPhysicsGene-expressionEscherichia coliPhage-lambdaNoiseStochasticityRobustnessKramersClocksAdaptation, physiologicalAlgorithmsAnimalsComputer simulationGenes, regulatorHumansModels, geneticSignal transductionTranscription factorsTranscriptional activationArticle10.1103/PhysRevE.71.01190251954