Mukamal, KennethTrinkaus-Randall, VickeryChen, Leslie Lien2025-09-242025-09-242024https://hdl.handle.net/2144/513122024BACKGROUND: Little is known about the short-term effects of light alcohol intake on sleep, depressive symptoms, and pain among women on aromatase inhibitor therapy.OBJECTIVE: To examine changes in sleep quality, depressive symptoms, and pain following white wine compared to white grape juice among 20 postmenopausal women. METHODS: We conducted a 10-week randomized controlled two-period crossover trial from September 2022 to July 2023 among 20 postmenopausal women with estrogen receptor-positive breast cancer taking aromatase inhibitors to examine alcohol effects on sex hormones. We also measured sleep, pain, and depressive symptoms. We used mixed models to examine within-person changes in health characteristics following 3 weeks of 5 ounces of white wine daily versus 3 weeks of 6 ounces of white grape juice daily, with each drinking period preceded by a two-week washout period and sequence of drinking periods allocated by randomization. RESULTS: All 20 randomized women completed the trial. There were no statistically significant changes following wine compared to grape juice. There were no meaningful changes in sleep quality, a trend toward a slight increase in pain intensity, and a slight decrease in depressive symptoms during the wine period. These effects were not large enough to have clinically meaningful implications. CONCLUSIONS: These data suggest that one serving of alcohol daily for three weeks did not have clinically meaningful effects on sleep quality, depressive symptoms, or pain intensity.en-USPublic healthAlcoholAromatase inhibitorsBreast cancerDepressionPainSleepThesis/Dissertation2025-09-24