Lajoie, SamuelWeinstein, John R.Statz, Branden Michael2022-02-182022-02-182021https://hdl.handle.net/2144/43885BACKGROUND: The burden of Crohn’s Disease (CD) on patients’ functional status, interpersonal relationships, and self-image is well documented. Additionally, recent advances in the understanding of the gut-brain axis have alluded to the potential role of psychological treatments in the reduction of CD activity. More recent consensus guidelines for the treatment of this disease advocate for addressing the psychosocial needs of CD patients, however the efficacy of cognitive behavioral therapy (CBT) in this patient population is unclear. Prior studies have found mixed results, but have been hindered by poorly targeted study populations. METHODS: The proposed study aims to explore the use of CBT in patients with CD utilizing improved study population selection. This will be a randomized controlled trial which will assess the effect of CBT on health-related quality of life (HRQOL) and disease activity in patients with moderate to severe CD. DISCUSSION: This study will help determine if CBT is an effective adjuvant treatment modality to the current medical management of CD. It would have far-reaching implications, resulting in decreased sequelae of CD and improved HRQOL.en-USMedicineThesis/Dissertation2022-02-13