Symes, KarenCullion, KathleenPetishnok, Laura Catherine2018-08-132018https://hdl.handle.net/2144/30747Research suggests biological sex differences may affect pain perception, however the difference in analgesic tolerance between male and females not been extensively studied. Therefore, here we studied the response of male and female Sprague-Dawley rats to prolonged duration local anesthetics; including conventional amino-amide anesthetics (bupivacaine), site 1 sodium channel blockers (tetrodotoxin) and a prolonged duration liposomal formulation (Exparel). This study examined the incidence and duration of sensory and motor blockade; systemic side effects, as well as local neurotoxicity and myotoxicity in both male and female rodents in an in vivo model of sciatic nerve blockade. The data collected does not indicate a sexual dimorphism among the agents studied.en-USMedicineBupivacaineLiposomal bupivacaineLocal anestheticsSexual dimorphismTetrodotoxinThesis/Dissertation2018-07-03