Spieler, Gary L.2023-03-242023-03-2419741974https://hdl.handle.net/2144/45935PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (M.Sc.D.)--Boston University, School of Graduate Dentistry. Dept. of Endodontics, 1974.Includes bibliography: leaves 29-32.The purpose of this investigation is to determine in a qualitative manner, the presence of a collagenolytic enzyme in teeth with lesions of endodontic origin. A reconstituted collagen-gel substrate enzyme assay system was employed. Varying degrees of collagenolysis was noted and compared to known dilutions of bacterial collagenase. No correlation to clinical symptomology was attempted in this study. Candidates for this study consisted of the following: (1) Eleven teeth which were candidates for periapical surgery. (2) Ten teeth diagnosed as pulpless and in need of endodontic intervention. (3) Four teeth with healthy pulps extracted for orthodontic purposes to serve as controls.en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.CollagenasesPeriapical DiseasesThesis/Dissertation