Garzon, Paola Andrea Hurtado2019-05-162019-05-1620082008(OCoLC)301735304(OCoLC)301735304b29637168https://hdl.handle.net/2144/35610Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2008 (Dept. of Periodontology and Oral Biology).Includes bibliographical references: leaves 130-153.Lysyl oxidase (LOX) is the enzyme that catalyzes the formation of aldehydes from lysine residues in collagen and elastin resulting in cross-linking. LOX plays a very important role in extracellular matrix deposition and maturation. In the context of cardiovascular disease, it has been stated that LOX is up-regulated in fibrotic diseases suggesting that LOX regulation could contribute to cardiovascular diseases. TNF-a is a major pro-inflammatory cytokine that controls some of the pathologies associated with the development of atherosclerosis following vascular injury, however, little is known about the effect of this cytokine on the regulation of lysyl oxidase in cardiovascular tissues. [TRUNCATED]en-USThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.Cardiovascular diseasesMuscle, smoothProtein-lysine 6-oxidaseOral biologyPeriodontologyLysyl oxidaseTumor necrosis factor-alphaThesis/Dissertation