Kajuluri, Lova PrasadareddySingh, KuldeepMorgan, Kathleen G.2023-04-132023-04-132021L.P. Kajuluri, K. Singh, K.G. Morgan. 2021. "Vascular aging, the vascular cytoskeleton and aortic stiffness." Explor Med, Volume 2, pp.186-197. https://doi.org/10.37349/emed.2021.000412692-3106https://hdl.handle.net/2144/46041Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth muscle cell (VSMC). This review will highlight the mechanisms by which the VSMC contributes to disorders of vascular aging. Distinct functional sub-components of the vascular cell and the molecular mechanisms of the protein-protein interactions, signaling mechanisms and intracellular trafficking processes in the setting of the aging aorta will be detailed.p. 186-197Print-ElectronicenCopyright: © The Author(s) 2021. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were madehttp://creativecommons.org/licenses/by/4.0/Vascular agingAortic stiffnessCytoskeletonFocal adhesionArticle2023-01-3010.37349/emed.2021.000410000-0003-1989-166X (Kajuluri, Lova Prasadareddy)0000-0001-7187-4782 (Singh, Kuldeep)0000-0003-3300-3630 (Morgan, Kathleen G)642689