Barbato, Keith StevenLuan, YiRamella, DanielePanek, James S.Schaus, Scott E.2024-02-292024-02-292015-12-04K.S. Barbato, Y. Luan, D. Ramella, J.S. Panek, S.E. Schaus. 2015. "Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols" Organic Letters, Volume 17, Issue 23, pp.5812-5815. https://doi.org/10.1021/acs.orglett.5b029541523-70601523-7052https://hdl.handle.net/2144/48259Chiral diols and biphenols catalyze the multicomponent condensation reaction of phenols, aldehydes, and alkenyl or aryl boronates. The condensation products are formed in good yields and enantioselectivities. The reaction proceeds via an initial Friedel-Crafts alkylation of the aldehyde and phenol to yield an ortho-quinone methide that undergoes an enantioselective boronate addition. A cyclization pathway was discovered while exploring the scope of the reaction that provides access to chiral 2,4-diaryl chroman products, the core of which is a structural motif found in natural products.pp. 5812-5815Print-ElectronicenScience & technologyPhysical sciencesChemistry, organicChemistryOrtho-quinone methidesAsymmetric allylborationIn-situConjugate additionNatural-productBoronic estersAcid catalysisDragons bloodVinyl ethersEnonesChemical sciencesOrganic chemistryAlcoholsAldehydesAlkylationBiological productsBoronic acidsCatalysisChromansCyclizationIndolequinonesMolecular structurePhenolsStereoisomerismArticle2024-01-1910.1021/acs.orglett.5b029540000-0002-5733-2511 (Panek, James S)50466