Yueh, HanGao, QiwenPorco, John A.Beeler, Aaron B.2018-12-172018-12-172017-12-01Han Yueh, Qiwen Gao, John A Porco, Aaron B Beeler. 2017. "A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues." Bioorganic & Medicinal Chemistry, Volume 25, Issue 23, pp. 6197 - 6202 (6). https://doi.org/10.1016/j.bmc.2017.06.0100968-08961464-3391https://hdl.handle.net/2144/32940Published in final edited form as: Bioorg Med Chem. 2017 Dec 1; 25(23): 6197–6202. Published online 2017 Jun 11. doi: [10.1016/j.bmc.2017.06.010]Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2]-photocycloaddition of 2-(p-methoxyphenyl)-3-hydroxyflavone and cinnamate-derived dipolarophiles. These reactors can be efficiently numbered up to increase throughput two orders of magnitude greater than the corresponding batch reactions.p. 6197 - 6202Science & technologyLife sciences & biomedicinePhysical sciencesBiochemistry & molecular biologyChemistry, medicinalChemistry, organicPharmacology & pharmacyChemistryPhotochemistryFlow chemistryESIPTPhotocycloadditionRocaglateNatural productAglainAlkaloidsBenzofuransBiological productsCinnamatesCycloaddition reactionFlavonoidsLightPhotochemical processesMedicinal and biomolecular chemistryPharmacology and pharmaceutical sciencesOrganic chemistryArticle10.1016/j.bmc.2017.06.010