Wilson, Toby S.2022-06-062022-06-0620012001(OCoLC)47816561b24035981https://hdl.handle.net/2144/44682PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2001.Includes bibliographical references (leaves 87-115).Bacteria and host factors found in lesions of endodontic origin regulate transcription of inflammatory cytokines and chemoattractant proteins. An important cytokine is monocyte chemoattractant protein-1 (MCP-1). MCP-1 is expressed by osteoblasts and functions to stimulate monocyte recruitment, as well as, bone formation, indirectly, in LEOs. The purpose of this study was to determine if Porphyromonas gingivalis, a common pathogen in LEOs, and interleukin-1 (IL-1), an important host bone resorbing cytokine involved in LEO formation, induce MCP-1 expression via different transcription factors. [TRUNCATED]en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Porphyromonas gingivalisReceptors, interleukin-1.Trans-activators.Thesis/Dissertation