Al-Hashemi, JacobHuck, OlivierDrizik, EduardGower, AdamDavideau, Jean-LucTenenbaum, HenriAmar, Salomon2016-05-232016-05-232016-04-10https://hdl.handle.net/2144/16372We analyzed bacterial modulation of miRNAs in bone-marrow- derived macrophages (BMMs) induced by infection with either wild type Porphyromonas gingivalis (Pg) or mutant Pg (∆FimA), through a microarray analysis. TNF-α and IL-10 concentrations in Pg infected BMMs transfected with selected miRNAs were also assessed. The inhibition of mmu-miR-2137 increased the secretion of anti-inflammatory IL-10, while mmu-miR-155-5p decreased TNF-α. In vivo: injecting these miRNAs with Pg in mice reduced the size of the lesion significantly.en-USOther