Flores, Francisco J.Dalla Betta, IsabellaTauber, JohnSchreier, David R.Stephen, Emily P.Wilson, Matthew A.Brown, Emery N.2025-02-202025-02-202024F.J. Flores, I. Dalla Betta, J. Tauber, D.R. Schreier, E.P. Stephen, M.A. Wilson, E.N. Brown. 2024. "Electrographic seizures during low-current thalamic deep brain stimulation in mice." Brain Stimulation, Volume 17, Issue 5, pp.975-979. https://doi.org/10.1016/j.brs.2024.08.0021935-861X1876-4754https://hdl.handle.net/2144/49838BACKGROUND: Deep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT). OBJECTIVES: To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice. METHODS: Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration. RESULTS: In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 μA. CONCLUSION: Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.pp. 975-979Print-ElectronicenAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Deep-brain stimulationElectric stimulationElectroencephalographySeizureThalamusMedical and health sciencesNeurology & neurosurgeryBiomedical and clinical sciencesHealth sciencesAnimalsDeep brain stimulationMiceSeizuresElectroencephalographyThalamusMaleMice, inbred C57BLArticle10.1016/j.brs.2024.08.0020000-0003-1978-9622 (Stephen, Emily P)973780