Cho, Gyusik2018-10-312018-10-3120152015(OCoLC)927023218(OCoLC)ocn927023218https://hdl.handle.net/2144/31775PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2015 (Department of Molecular and Cell Biology).Includes bibliography: leaves 35-44.Patients undergoing phenytoin treatment may develop gingival overgrowth as a side effect. During drug-induced gingival overgrowth (DIGO), epithelial tissues will go through epithelial to mesenchymal transition (EMT) to become more like cormective tissue. EMT is associated with fibrosis as well as cancer. Objectives: The objective of this experiment is to investigate TGF-beta expression in posterior gingival epithelial and comective tissues of phenytoin treated mice in order to assess for a correlation between TGF-beta expression and gingival overgrowth in mice. The overall hypothesis is that since the gingival overgrowth does not happen extensively in the posterior gingival tissues, TGF-beta expression may not be highly expressed in the posterior gingival tissues. This study is a part of a larger prqiect to replicate human Phenytoin-induced gingival overgrowth in a mouse model in order to study and ... [TRUNCATED]en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Transforming growth factor betaGingivaPhenytoinMiceThesis/Dissertation99208278480001161