Ingham, Oscar J.Paranal, Ronald M.Smith, William B.Escobar, Randolph A.Yueh, HanSnyder, TracyPorco, John A.Bradner, James E.Beeler, Aaron B.2018-01-302018-01-302016-10-13Oscar J Ingham, Ronald M Paranal, William B Smith, Randolph A Escobar, Han Yueh, Tracy Snyder, John A Porco, James E Bradner, Aaron B Beeler. 2016. "Development of a Potent and Selective HDAC8 Inhibitor.." ACS Med Chem Lett, Volume 7, Issue 10, pp. 929 - 932.1948-5875https://hdl.handle.net/2144/26485A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.pp. 929 - 932© 2016 American Chemical SocietyScience & technologyLife sciences & biomedicineChemistry, medicinalPharmacology & pharmacyHistone deacetylaseHDACHistone deacetylase 8HDAC8TriazoleEpigeneticHistone deacetylase inhibitorsCorneliaCancerCycloadditionMedicinal and biomolecular chemistryPharmacology and pharmaceutical sciencesOrganic chemistryArticle10.1021/acsmedchemlett.6b00239