Li, YongxinOmori, AkihitoFlores, Rachel L.Satterfield, SheriNguyen, ChristineOta, TatsuyaTsurugaya, TokoIkuta, TetsuroIkeo, KazuhoKikuchi, ManiLeong, Jason C.K.Reich, AdrianHao, MengWan, WentingDong, YangRen, YaondongZhang, SiZeng, TaoUesaka, MasahiroUchida, YuiLi, XueyanShibata, Tomoko F.Bino, TakahiroOgawa, KotaShigenobu, ShujiKondo, MarikoWang, FayouChen, LuonanWessel, GarySaiga, HidetoshiCameron, R. AndrewLivingston, BrianBradham, Cynthia A.Wang, WenIrie, Naoki2024-03-262024-03-262020Y. Li, A. Omori, R.L. Flores, S. Satterfield, C. Nguyen, T. Ota, T. Tsurugaya, T. Ikuta, K. Ikeo, M. Kikuchi, J.C.K. Leong, A. Reich, M. Hao, W. Wan, Y. Dong, Y. Ren, S. Zhang, T. Zeng, M. Uesaka, Y. Uchida, X. Li, T.F. Shibata, T. Bino, K. Ogawa, S. Shigenobu, M. Kondo, F. Wang, L. Chen, G. Wessel, H. Saiga, R.A. Cameron, B. Livingston, C. Bradham, W. Wang, N. Irie. 2020. "Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms" Communications Biology, Volume 3, Issue 1. https://doi.org/10.1038/s42003-020-1091-12399-3642https://hdl.handle.net/2144/48498Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development of this unique transformation remains to be clarified. Here we report newly sequenced genomes, developmental transcriptomes, and proteomes of diverse echinoderms including the green sea urchin (L. variegatus), a sea cucumber (A. japonicus), and with particular emphasis on a sister group of the earliest-diverged echinoderms, the feather star (A. japonica). We learned that the last common ancestor of echinoderms retained a well-organized Hox cluster reminiscent of the hemichordate, and had gene sets involved in endoskeleton development. Further, unlike in other animal groups, the most conserved developmental stages were not at the body plan establishing phase, and genes normally involved in bilaterality appear to function in pentameric axis development. These results enhance our understanding of the divergence of protostomes and deuterostomes almost 500 Mya.en© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.https://creativecommons.org/licenses/by/4.0/Biological sciencesBiomedical and clinical sciencesArticle2024-02-0810.1038/s42003-020-1091-10000-0003-0571-6553 (Omori, Akihito)0000-0002-1115-5169 (Ota, Tatsuya)0000-0002-1680-8659 (Reich, Adrian)0000-0001-6212-3055 (Dong, Yang)0000-0002-0295-3994 (Zeng, Tao)0000-0003-0457-7846 (Li, Xueyan)0000-0003-4640-2323 (Shigenobu, Shuji)0000-0002-8072-2729 (Kondo, Mariko)0000-0002-3960-0068 (Chen, Luonan)0000-0003-3947-6041 (Cameron, R Andrew)0000-0002-7801-2066 (Wang, Wen)0000-0002-6720-381X (Irie, Naoki)599883