Postnov, Dmitry D.Erdener, Sefik EvrenKilic, KivilcimBoas, David A.2019-09-062019-09-062018-12-01Dmitry D Postnov, Sefik Evren Erdener, Kivilcim Kilic, David A Boas. 2018. "Cardiac pulsatility mapping and vessel type identification using laser speckle contrast imaging." BIOMEDICAL OPTICS EXPRESS, Volume 9, Issue 12, pp. 6388 - 6397 (10). https://doi.org/10.1364/BOE.9.0063882156-7085https://hdl.handle.net/2144/37739Systemic flow variations caused by the cardiac cycle can play a role or be an important marker in both normal and pathological conditions. The shape, magnitude and propagation speed of the flow pulse reflect mechanical properties of the vasculature and are known to vary significantly with vascular diseases. Most conventional techniques are not capable of imaging cardiac activity in the microcirculation due to spatial and/or temporal resolution limitations and instead make inferences about propagation speed by making measurements at two points along an artery. Here, we apply laser speckle contrast imaging to images with high spatial resolution in the high frequency harmonics of cardiac activity in the cerebral cortex of a mouse. We reveal vessel dependent variation in the cardiac pulse activity and use this information to automatically identify arteries and veins.6388 - 6397 (10)© 2018 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.Life sciences & biomedicineBiochemical research methodsOpticsRadiology, nuclear medicine & medical imagingBiochemistry & molecular biologyArticle10.1364/BOE.9.0063880000-0002-6709-7711 (Boas, David A)414610