Richardson, John F.2019-10-222019-10-2219721972b14299458https://hdl.handle.net/2144/38316PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (D.Sc.D.)--Boston University School of Graduate Dentistry, 1972. (Oral pathology)Bibliography included.An experimental study was carried out to determine the effect of environmental hormone (androgen) imbalance on induced chemical (DMBA) carcinogenesis of the mouse submaxillary gland, a tissue whose parenchymal elements reflect both biochemically and morphologically, the nonphysiologic hormone alterations. Male Swiss-Webster mice (CD/1 strain) were challenged with DMBA via intraglandular implantation under conditions of hormone homeostasis as well as deprivation or excess or both in sequence. It was noted that, when compared with challenged intact animals, the tumor latency period was shortened and the yield markedly increased under conditions of hormone alteration. There were, however, distinct variations between groups reflecting the effect of distinctly different mechanisms operative in the process of enhancement of the neoplastic potential of the glandular cells.en-USThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Submandibular glandJaw neoplasmsAndrogensCarcinosarcomaThesis/Dissertation