Alzeitani, Mohammed Tareq2022-04-042022-04-0420072007(OCoLC)234233614(OCoLC)234233614b27872634https://hdl.handle.net/2144/44135Thesis (MSD)--Boston University, Henry M. Goldman School of Dental Medicine, 2007 (Orthodontics and Dentofacial Orthopedics).Includes bibliographical references: leaves 87-100.Orthodontic tooth movement is a non-pathologic inflammatory process that involves the recruitment of different cell types responsible for alveolar bone modeling. An increase in this non-pathologic inflammatory response will result in an increase in tooth movement velocity. Selective alveolar bone decortication has been shown to increase the rate of bone turnover resulting in both shorter treatment time, and less relapse. PURPOSE: The purpose of this study was to examine for differences in systemic cytokine profiles during tooth movement and relapse, with and without selective alveolar decortication. METHODS: Sprague-Dawley rats (n=153) were divided into 10 groups. Group I served as the baseline. Groups 2 to 6 were observed up to 6 weeks and were divided into 3 groups: tooth movement only, corticotomy only, and corticotomy plus tooth movement. After 6 weeks of tooth movement, relapse was observed in the remaining 4 groups for up to 6 weeks. Relapse was observed as a function of time after tooth movement only and after corticotomy facilitated tooth movement. Ten different cytokine targets (GM-CSF, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, IFN-γ, and TNF-α) were analyzed for all subjects using Multiplexed Bead-Based Bioassay that was analyzed by the Luminex 100 [TM] instrument. [TRUNCATED]en-USThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.Alveolar bone lossCytokinesTooth movementThesis/Dissertation