Grossberg, Stephen2018-03-082018-03-082017-11Grossberg S (2017) Acetylcholine Neuromodulation in Normal and Abnormal Learning and Memory: Vigilance Control in Waking, Sleep, Autism, Amnesia and Alzheimer’s Disease. Front. Neural Circuits. 11:82. doi: 10.3389/fncir.2017.00082https://hdl.handle.net/2144/27416This article provides a unified mechanistic neural explanation of how learning, recognition, and cognition break down during Alzheimer's disease, medial temporal amnesia, and autism. It also clarifies whey there are often sleep disturbances during these disorders. A key mechanism is how acetylcholine modules vigilance control in cortical layer 5Copyright © 2017 Grossberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Adaptive resonance theoryAutismAlzheimer's diseaseAcetylcholineMedial temporal amnesiaSlow wave sleep10.3389/fncir.2017.00082