Gervais, AnaisLazarski, Kiel E.Porco, John A.2018-01-302018-01-302015-10-02Anais Gervais, Kiel E Lazarski, John A Porco. 2015. "Divergent Total Syntheses of Rhodomyrtosones A and B.." J Org Chem, Volume 80, Issue 19, pp. 9584 - 9591.1520-6904https://hdl.handle.net/2144/26494Herein, we report total syntheses of the tetramethyldihydroxanthene natural product rhodomyrtosone B and the related bis-furan β-triketone natural product rhodomyrtosone A. Nickel-(II)-catalyzed 1,4-conjugate addition of an α-alkylidene-β-dicarbonyl substrate was developed to access the congener rhodomyrtosone B, and oxygenation of the same monoalkylidene derivative followed by cyclization was employed to obtain the bis-furan natural product rhodomyrtosone A.9584 - 9591Science & technologyPhysical sciencesChemistry, organicChemistryOrtho-quinone methidesFlow photochemistryConjugate additionMeldrums acidsAcylphloroglucinolsEndoperoxideTomentosaBiological productsCatalysisCyclizationFuransHeterocyclic compounds, 3-ringKetonesMolecular structureNickelStereoisomerismMedicinal and biomolecular chemistryOrganic chemistryInorganic chemistryArticle10.1021/acs.joc.5b01570