Nieto-Castanon, AlfonsoGhosh, SatrajitTourville, JasonGuenther, Frank H.2011-11-142011-11-142002-09https://hdl.handle.net/2144/2298In this technical report, we present fMRI analysis techniques that test functional hypotheses at the region of interest (ROI) level. An SPM-compatible Matlab toolbox has been developed which allows the creation of subject-specific ROI masks based on anatomical markers and the testing of functional hypotheses on the regional response using multivariate time-series analysis techniques. The combined application of subject-specific ROI definition and region-level functional analysis is shown to appropriately compensate for inter-subject anatomical variability, offering finer localization and increased sensitivity to task-related effects than standard techniques based on whole brain normalization and voxel or cluster-level functional analysis, while providing a more direct link between discrete brain region hypotheses and the statistical analyses used to test them.en-USCopyright 2002 Boston University. Permission to copy without fee all or part of this material is granted provided that: 1. The copies are not made or distributed for direct commercial advantage; 2. the report title, author, document number, and release date appear, and notice is given that copying is by permission of BOSTON UNIVERSITY TRUSTEES. To copy otherwise, or to republish, requires a fee and / or special permission.fMRIMRIMethodsRegion of interestAnatomical variabilityMultivariate analysisTechnical ReportBoston University Trustees