Hsu, Tun-YiZhu, XiaofeiZaman, Fahad2025-07-302025-07-302025https://hdl.handle.net/2144/507732025CBCT studies studying the optimal location for needle placement when delivering an IANB reveal promising generalizations and enhanced success with modification of classical technique, but no study has compared individualized clinical effectiveness. Current devices do not consider each patient’s unique anatomy via CBCT. This thesis focuses on the development of a custom IANB device to be used in a future clinical trial. Due to the unique bite plate, horizontal guide tubes’ angulation and size, full arch span, lingual height of contour exclusion, and no windows; experimentation to determine which DLP 3D printer had the most accurate and precise internal tolerance reproduction and where the highest accuracy was on the build plates was needed. Ex vivo laboratory study using three DLP printers and five cadaveric mandibles. 135 or 75 test cylinders were printed per printer across multiple build‑plate locations. Twenty guided IANB placements were performed on cadaver mandibles. In the nonparametric analysis of internal and external deviation for three printers, the middle build location showed statistically significantly better results compared to edge locations (Kruskal Wallis, p<0.01). Asiga was the most consistent across the plate (100% freed cylinders from the enclosure), followed by Carbon (91%), and Sprint Ray (72%). The middle of Carbon’s platform was used for the final device production. Our device achieved the lowest direct deviation of 0.696 (+/- 0.273) mm in the frontal view, reaching 1.059 (+/- 0.388) mm of direct deviation in the sagittal view. The most deviation was Anterior-Posteriorly (0.482 & 0.972 mm), followed by Buccal-Lingually (0.43 & 0.611 mm), and Superior-Inferiorly (0.388 & 0.437 mm). The average angular deviation was 1.004° (+/- 0.712°).en-USAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/DentistryBioengineeringDynamic navigationGuided anesthesiaGuided blockIANBInferior alveolar nerve blockStatic guideThesis/Dissertation2025-07-29