Scholvin, JoergZorzos, AnthonyKinney, JustinBernstein, JacobMoore-Kochlacs, CarolineKopell, NancyFonstad, CliftonBoyden, Edward S.2020-04-162020-04-162018-09-01Joerg Scholvin, Anthony Zorzos, Justin Kinney, Jacob Bernstein, Caroline Moore-Kochlacs, Nancy Kopell, Clifton Fonstad, Edward S Boyden. 2018. "Scalable, Modular Three-Dimensional Silicon Microelectrode Assembly via Electroless Plating." MICROMACHINES, Volume 9, Issue 9. https://doi.org/10.3390/mi90904362072-666Xhttps://hdl.handle.net/2144/40209We devised a scalable, modular strategy for microfabricated 3-D neural probe synthesis. We constructed a 3-D probe out of individual 2-D components (arrays of shanks bearing close-packed electrodes) using mechanical self-locking and self-aligning techniques, followed by electroless nickel plating to establish electrical contact between the individual parts. We detail the fabrication and assembly process and demonstrate different 3-D probe designs bearing thousands of electrode sites. We find typical self-alignment accuracy between shanks of <0.2° and demonstrate orthogonal electrical connections of 40 µm pitch, with thousands of connections formed electrochemically in parallel. The fabrication methods introduced allow the design of scalable, modular electrodes for high-density 3-D neural recording. The combination of scalable 3-D design and close-packed recording sites may support a variety of large-scale neural recording strategies for the mammalian brain.21 pages.en-USThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/Science & technologyTechnologyNanoscience & nanotechnologyInstruments & instrumentationElectrode arrayMicroelectrodesNeural recordingSilicon probeThree-dimensionalElectroless platingLarge-scaleBrain activityRibbon cablesNeural probeHigh-densityArrayMicroprobesResolutionCircuitsCortexArticle10.3390/mi90904360000-0002-8568-8750 (Kopell, Nancy)406294