Wang, LuFreedman, DavidSahin, MesutÜnlü, M. SelimKnepper, Ronald2018-05-102018-05-102016-02-04Wang, L.; Freedman, D.; Sahin, M.; Ünlü, M.S.; Knepper, R. Active C4 Electrodes for Local Field Potential Recording Applications. Sensors 2016, 16, 198.1424-8220https://hdl.handle.net/2144/28869Extracellular neural recording, with multi-electrode arrays (MEAs), is a powerful method used to study neural function at the network level. However, in a high density array, it can be costly and time consuming to integrate the active circuit with the expensive electrodes. In this paper, we present a 4 mm × 4 mm neural recording integrated circuit (IC) chip, utilizing IBM C4 bumps as recording electrodes, which enable a seamless active chip and electrode integration. The IC chip was designed and fabricated in a 0.13 μm BiCMOS process for both in vitro and in vivo applications. It has an input-referred noise of 4.6 μV rms for the bandwidth of 10 Hz to 10 kHz and a power dissipation of 11.25 mW at 2.5 V, or 43.9 μW per input channel. This prototype is scalable for implementing larger number and higher density electrode arrays. To validate the functionality of the chip, electrical testing results and acute in vivo recordings from a rat barrel cortex are presented.This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).http://creativecommons.org/licenses/by/4.0/Science & technologyPhysical sciencesChemistry, analyticalElectrochemistryInstruments & instrumentationChemistryC43D electrodesMEAIn vivoExtracellularIn vitroNeural sensorsCMOSBrainNeurostimulationAction potentialsAmplifiers, electronicAnimalsCerebellar cortexMicroelectrodesNerve netNeuronsRatsAnalytical chemistryElectrical and electronic engineeringArticle10.3390/s160201980000-0002-8594-892X (Ünlü, M Selim)