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Experimental Validation of the Influence of White Matter Anisotropy on the Intracranial EEG Forward Solution

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dc.contributor.author Bangera, Nitin B. en_US
dc.contributor.author Schomer, Donald L. en_US
dc.contributor.author Dehghani, Nima en_US
dc.contributor.author Ulbert, Istvan en_US
dc.contributor.author Cash, Sydney en_US
dc.contributor.author Papavasiliou, Steve en_US
dc.contributor.author Eisenberg, Solomon R. en_US
dc.contributor.author Dale, Anders M. en_US
dc.contributor.author Halgren, Eric en_US
dc.date.accessioned 2012-01-11T00:39:12Z
dc.date.available 2012-01-11T00:39:12Z
dc.date.issued 2010-1-9 en_US
dc.identifier.citation Bangera, Nitin B., Donald L. Schomer, Nima Dehghani, Istvan Ulbert, Sydney Cash, Steve Papavasiliou, Solomon R. Eisenberg, Anders M. Dale, Eric Halgren. "Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution" Journal of Computational Neuroscience 29(3): 371-387. (2010) en_US
dc.identifier.issn 1573-6873 en_US
dc.identifier.uri http://hdl.handle.net/2144/3013
dc.description.abstract Forward solutions with different levels of complexity are employed for localization of current generators, which are responsible for the electric and magnetic fields measured from the human brain. The influence of brain anisotropy on the forward solution is poorly understood. The goal of this study is to validate an anisotropic model for the intracranial electric forward solution by comparing with the directly measured 'gold standard'. Dipolar sources are created at known locations in the brain and intracranial electroencephalogram (EEG) is recorded simultaneously. Isotropic models with increasing level of complexity are generated along with anisotropic models based on Diffusion tensor imaging (DTI). A Finite Element Method based forward solution is calculated and validated using the measured data. Major findings are (1) An anisotropic model with a linear scaling between the eigenvalues of the electrical conductivity tensor and water self-diffusion tensor in brain tissue is validated. The greatest improvement was obtained when the stimulation site is close to a region of high anisotropy. The model with a global anisotropic ratio of 10:1 between the eigenvalues (parallel: tangential to the fiber direction) has the worst performance of all the anisotropic models. (2) Inclusion of cerebrospinal fluid as well as brain anisotropy in the forward model is necessary for an accurate description of the electric field inside the skull. The results indicate that an anisotropic model based on the DTI can be constructed non-invasively and shows an improved performance when compared to the isotropic models for the calculation of the intracranial EEG forward solution. ELECTRONIC SUPPLEMENTARY MATERIAL. The online version of this article (doi:10.1007/s10827-009-0205-z) contains supplementary material, which is available to authorized users. en_US
dc.description.sponsorship National Institutes of Health (NS44623, NS18741); Trustees of Boston University en_US
dc.language.iso en en_US
dc.publisher Springer US en_US
dc.rights Copyright The Author(s) 2009 en_US
dc.subject Forward solution en_US
dc.subject White matter anisotropy en_US
dc.subject Intracranial EEG en_US
dc.subject Validation en_US
dc.subject FEM en_US
dc.subject Finite element model en_US
dc.subject Source localization en_US
dc.title Experimental Validation of the Influence of White Matter Anisotropy on the Intracranial EEG Forward Solution en_US
dc.type article en_US
dc.identifier.doi 10.1007/s10827-009-0205-z en_US
dc.identifier.pubmedid 20063051 en_US
dc.identifier.pmcid 2912982 en_US


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