2014 REU Poster: Total Synthesis of Myxopyronin
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Myxopyronin A and B was first isolated in the early 1980s from the bacteria Myxococcus fulvus. These molecules possess a single stereocenter with a (R) – configuration. The ability to inhibit the growth of several Gram-positive and Gram-negative bacteria and to selectively target bacteria RNA polymerase over human polymerase makes Myxopyronin a molecule worth studying. This project approaches the total synthesis of Myxopyronin via racemic and asymmetric routes.
Poster presentation at REU Summer's End Research Symposium, 2014, by International REU participant Linus Lim, National University of Singapore - James Panek group, Bin Cai lab mentor.