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dc.contributor.authorKraus, Benjamin J.en_US
dc.contributor.authorBrandon, Mark P.en_US
dc.contributor.authorRobinson, Robert J.en_US
dc.contributor.authorConnerney, Michael A.en_US
dc.contributor.authorHasselmo, Michael E.en_US
dc.contributor.authorEichenbaum, Howarden_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2017-05-22T13:50:38Z
dc.date.available2017-05-22T13:50:38Z
dc.date.issued2015-11-04
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/26539893
dc.identifier.citationBenjamin J Kraus, Mark P Brandon, Robert J Robinson, Michael A Connerney, Michael E Hasselmo, Howard Eichenbaum. 2015. "During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run.." Neuron, Volume 88, Issue 3, pp. 578 - 589. doi:10.1016/j.neuron.2015.09.031
dc.identifier.issn1097-4199
dc.identifier.urihttps://hdl.handle.net/2144/22235
dc.description.abstractThe spatial scale of grid cells may be provided by self-generated motion information or by external sensory information from environmental cues. To determine whether grid cell activity reflects distance traveled or elapsed time independent of external information, we recorded grid cells as animals ran in place on a treadmill. Grid cell activity was only weakly influenced by location, but most grid cells and other neurons recorded from the same electrodes strongly signaled a combination of distance and time, with some signaling only distance or time. Grid cells were more sharply tuned to time and distance than non-grid cells. Many grid cells exhibited multiple firing fields during treadmill running, parallel to the periodic firing fields observed in open fields, suggesting a common mode of information processing. These observations indicate that, in the absence of external dynamic cues, grid cells integrate self-generated distance and time information to encode a representation of experience.en_US
dc.description.sponsorshipMH095297 - NIMH NIH HHS; R01 MH095297 - NIMH NIH HHS; MH071702 - NIMH NIH HHS; R01 MH060013 - NIMH NIH HHS; P50 MH071702 - NIMH NIH HHS; MH060013 - NIMH NIH HHSen_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635558/
dc.format.extent578 - 589en_US
dc.languageeng
dc.relation.ispartofNeuron
dc.subjectAction potentialsen_US
dc.subjectAnimalsen_US
dc.subjectElectrodes, implanteden_US
dc.subjectEntorhinal cortexen_US
dc.subjectExercise testen_US
dc.subjectMaleen_US
dc.subjectRatsen_US
dc.subjectRats, Long-Evansen_US
dc.subjectRunningen_US
dc.subjectTime factorsen_US
dc.subjectLife Sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPrefrontal cortexen_US
dc.subjectPath-integrationen_US
dc.subjectNeural spikingen_US
dc.subjectMemoryen_US
dc.subjectHippocampusen_US
dc.subjectCognitive scienceen_US
dc.titleDuring running in place, grid cells integrate elapsed time and distance runen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1016/j.neuron.2015.09.031
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-9925-6377 (Hasselmo, Michael E)


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