The effect of Phentermine on weight loss in diabetic patients
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OBJECTIVE: The main objective of the study is to evaluate the effect of short-term use of Phentermine on weight loss in subjects with diabetes compared to those without. STUDY DESIGN AND PARTICIPANTS: This retrospective cohort study followed a group of individuals with obesity in a non-surgical weight management program who took Phentermine for an average of 3 continuous months. Of the 605 eligible patients who have started taking Phentermine between January 2015 and June 2015, 285 patients were included in the study. Patients taking other weight loss medications, patients with missing data [height, weight, hemoglobin A1c (HbA1c)], patients lost to follow up, and patients under the age of 21 or over 65 were excluded from the study. MAIN OUTCOMES AND MEASURES: The primary outcome is percentage weight loss after an average of 3 months of continuous use of Phentermine. Clinical variables obtained from medical records included HbA1c level, home medications, labs, gender, age, first date of Phentermine prescription, date of Phentermine discontinuation, and weight at each visit. RESULTS: Most participants (91.58%) lost weight. Among those with a normal HbA1c level (HbA1c <5.7) (n=155), 89.68% lost weight, while 93.33 % of pre-diabetics (HbA1c >=5.7 and <6.5) (n=90) lost weight, and 92.5% of diabetics (HbA1c >=6.5) (n=40) lost weight. The mean % weight loss for all participants (n=285) was 5.47% (SD=4.39). Those without diabetes or pre-diabetes had a mean % weight loss of 5.59% (SD=4.78); pre-diabetics lost 5.67% (SD=4.17) on average while diabetics lost 4.53 %(SD=3.06) of their total body weight (P-value for between group difference in percent weight loss=0.3413). The Bonferroni post hoc test also indicated that there was no significant difference in % weight loss between groups. CONCLUSION: Diabetic patients had a lower percentage weight loss compared to those with no diabetes or pre-diabetes after short-term use of continuous Phentermine. However, this finding did not provide statistical significance between the groups. Our finding also provided additional insight that the average age, months, and initial BMI between the groups were potential confounders in our study.