PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse
Zhang, G. L.
Srinivasan, K. N.
August, J. T.
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Citation (published version)G. L. Zhang, K. N. Srinivasan, A. Veeramani, J. T. August, V. Brusic. 2005. "PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse." Nucleic Acids Research, Volume 33, Issue Web Server, pp. W180 - W183.
PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd, H2-Ld and H2-Dd) and class II (I-Ed and I-Ad) molecules. The pre- diction system utilizes quantitative matrices, which were rigorously validated using experimentally deter- mined binders and non-binders and also by in vivo studies using viral proteins. The prediction perform- ance of PREDBALB/c is of very high accuracy. To our knowledge, this is the first online server for the pre- diction of peptides binding to a complete set of major histocompatibility complex molecules in a model organism (H2d haplotype). PREDBALB/c is available at http://antigen.i2r.a-star.edu.sg/predBalbc/.