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  • Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice 

    Sanoudou, D.; Duka, A.; Drosatos, K.; Hayes, K. C.; Zannis, V. I. (Nature Publishing Group, 2009-12-01)
    We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment. Multilevel bioinformatical ...
  • Identification of Positive Regulators of the Yeast Fps1 Glycerol Channel 

    Beese, Sara E.; Negishi, Takahiro; Levin, David E. (Public Library of Science, 2009-11-26)
    The yeast Fps1 protein is an aquaglyceroporin that functions as the major facilitator of glycerol transport in response to changes in extracellular osmolarity. Although the High Osmolarity Glycerol pathway is thought to ...
  • Discovery of a Novel and Rich Source of Gluten-Degrading Microbial Enzymes in the Oral Cavity 

    Helmerhorst, Eva J.; Zamakhchari, Maram; Schuppan, Detlef; Oppenheim, Frank G. (Public Library of Science, 2010-10-11)
    BACKGROUND. Celiac disease is a T cell mediated-inflammatory enteropathy caused by the ingestion of gluten in genetically predisposed individuals carrying HLA-DQ2 or HLA-DQ8. The immunogenic gliadin epitopes, containing ...
  • Toll-Like Receptor-2 Mediates Diet and/or Pathogen Associated Atherosclerosis: Proteomic Findings 

    Madan, Monika; Amar, Salomon (Public Library of Science, 2008-9-12)
    BACKGROUND. Accumulating evidence implicates a fundamental link between the immune system and atherosclerosis. Toll-like receptors are principal sensors of the innate immune system. Here we report an assessment of the role ...
  • The Jacob2 Lectin of the Entamoeba Histolytica Cyst Wall Binds Chitin and Is Polymorphic 

    Ghosh, Sudip K.; Van Dellen, Katrina L.; Chatterjee, Anirban; Dey, Tuli; Haque, Rashidul; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2010-7-20)
    BACKGROUND. The infectious and diagnostic form of Entamoeba histolytica (Eh), cause of amebic dysentery and liver abscess, is the quadranucleate cyst. The cyst wall of Entamoeba invadens (Ei), a model for Eh, is composed ...
  • Activin A Expression Regulates Multipotency of Mesenchymal Progenitor Cells 

    Djouad, Farida; Jackson, Wesley M.; Bobick, Brent E.; Janjanin, Sasa; Song, Yingjie; Huang, George T. J.; Tuan, Rocky S. (BioMed Central, 2010-5-4)
    INTRODUCTION. Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a ...
  • Evidence for a "Wattle and Daub" Model of the Cyst Wall of Entamoeba 

    Chatterjee, Anirban; Ghosh, Sudip K.; Jang, Ken; Bullitt, Esther; Moore, Landon; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2009-7-3)
    The cyst wall of Entamoeba invadens (Ei), a model for the human pathogen Entamoeba histolytica, is composed of fibrils of chitin and three chitin-binding lectins called Jacob, Jessie3, and chitinase. Here we show chitin, ...
  • Risk of Tooth Loss After Cigarette Smoking Cessation 

    Krall Kaye, Elizabeth; Dietrich, Thomas; Nunn, Martha E.; Garcia, Raul I. (Centers for Disease Control and Prevention, 2006-9-15)
    INTRODUCTION. Little is known about the effect of cigarette smoking cessation on risk of tooth loss. We examined how risk of tooth loss changed with longer periods of smoking abstinence in a prospective study of oral health ...
  • A New Brief Measure of Oral Quality of Life 

    Kressin, Nancy R; Jones, Judith A; Orner, Michelle B.; Spiro, Avron (Centers for Disease Control and Prevention, 2008-3-15)
    INTRODUCTION. We developed a brief measure of the impact of oral conditions on individual functioning and well-being, known as oral quality of life. METHODS. Among older male veterans (N = 827) and community dental patients ...
  • Trichomonas Transmembrane Cyclases Result from Massive Gene Duplication and Concomitant Development of Pseudogenes 

    Cui, Jike; Das, Suchismita; Smith, Temple F.; Samuelson, John (Public Library of Science, 2010-8-3)
    BACKGROUND. Trichomonas vaginalis has an unusually large genome (∼160 Mb) encoding ∼60,000 proteins. With the goal of beginning to understand why some Trichomonas genes are present in so many copies, we characterized here ...

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