Inferring Genome-Scale Rearrangement Phylogeny and Ancestral Gene Order: A Drosophila Case Study
Gelbart, William M
Smith, Temple F
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Citation (published version)Bhutkar, Arjun, William M Gelbart, Temple F Smith. "Inferring Genome-Scale Rearrangement Phylogeny and Ancestral Gene Order: A Drosophila Case Study" Genome Biology 8(11):R236. (2007)
A simple, fast, and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. This has been applied to eight Drosophila genomes. Existing techniques are either limited to a few hundred markers or a small number of taxa. This analysis uses over 14,000 genomic loci and employs discrete elements consisting of pairs of homologous genetic elements. The results provide insight into evolutionary chromosomal dynamics and synteny analysis, and inform speciation studies.
RightsCopyright 2007 Bhutkar et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.