Center for Molecular Discovery
The Boston University Center for Molecular Discovery (BU-CMD) is an integrated infrastructure for the discovery of new small molecule chemical probes, therapeutic leads, and therapeutic target pathways. The operations of BU-CMD consist of synthetic chemistry, high-throughput screening and biology (HTS), medicinal chemistry, and translational investigations.
HISTORY: The BU-CMD builds upon the foundation originally established by the Center for Chemical Methodology and Library Development at Boston University (CMLD-BU). Funded by the National Institute of General Medical Sciences (NIGMS) from 2001-2014, the CMLD-BU focused on the production of novel chemical libraries of unprecedented complexity for biological screening, publishing new protocols and methodologies for library synthesis, and providing chemical libraries to members of the biological research community to use as research tools in collaborative efforts.
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(Public Library of Science, 2009-4-29)BACKGROUND. Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of ...