Changes in fine structure of the frog lung induced by substances altering transcapillary exchange
Philpott, Delbert E.
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In order to evaluate the possible role of dynamic alterations, both reversible and irreversible, in the ultrastructure of the capillary wall as related to permeability, chemical substances known to alter transvascular exchange (moccasin snake venom, histamine and serotonin) were applied topically to the exposed lung of frogs, Rana pipiens and Rana catesbiana. Progressive stages of damage to lung and vascular tissues were revealed by electron microscopy. The speed of the response varied directly with the concentration and duration of application. The chemical concentrations were adjusted to produce all of the observable effects in about one half hour [TRUNCATED]
Thesis (Ph.D.)--Boston University
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