Studies concerning the histotoxic and neoplastic potential of isobutyl-2-cyanoacrylate and analysis of its effect on sequential wound healing when employed as an oral hemostat in the Long-Evans rat
Greer, Robert O.
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An experimental study was implemented to determine the effectiveness of isobutyl-2-cyanoacrylate (bucrylate) as an oral hemostat, its influence on sequential wound healing and its potential as a carcinogen. Segregated groups of equa] numbers of male and female Long-Evans Hooded Rats underwent deep (socket) and superficial (surface) aerosol placement of bucrylate to maxillary molar extraction sites. Bucrylate proved to be an effective oral hemostat, rapidly retarding postextraction hemorrhage. Deep placement of the adhesive resulted in retarded healing and lingering macrohistiocytic aggregates in wounds. Superficial placement of the material resulted in very little long term macrohistioeytic response and wound healing showed little retardation. A neoplastic potential was not demonstrated for bucrylate.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (D.Sc.D.)--Boston University School of Graduate Dentistry, 1974. Oral pathology.Bibliography included.
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