Cox-2: Where Are We in 2003? - The Role of Cyclooxygenase-2 in Bone Repair
Einhorn, Thomas A.
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Citation (published version)Einhorn, Thomas A. "Cox-2: Where are we in 2003? - The role of cyclooxygenase-2 in bone repair" Arthritis Research & Therapy 5(1): 5-7. (2002)
Prostaglandins are important mediators of bone repair, and cyclooxygenases are required for prostaglandin production. Data from animal studies suggest that both non-specific and specific inhibitors of cyclooxygenases impair fracture healing but that this is due to the inhibition of COX-2 and not COX-1. Although these data raise concerns about the use of COX-2-specific inhibitors as anti-inflammatory or anti-analgesic drugs in patients undergoing bone repair, clinical reports have been inconclusive. Because animal data suggest that the effects of COX-2 inhibitors are both dose-dependent and reversible, in the absence of scientifically sound clinical evidence it is suggested that physicians consider short-term administration or other drugs in the management of these patients.