The low-density lipoprotein receptor-related protein is a receptor for chylomicron remnants and alpha2-macroglobulin
Palmieri, Maria Lucia
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The low-density lipoprotein receptor-related protein (LRP) is a 4544 amino acid polypeptide with structural similarity to the low-density lipoprotein receptor. LRP contains two subunits, a 515kDa subunit and an 85kDa subunit. LRP is found in a wide range of tissues, although its main function is confined to the liver. LRP is an Apo E binding receptor, which led to the idea that it might serve to clear chylomicron remnants and large Beta-VLDL from the plasma. The majority of research supports this hypothesis, although a small amount of conflicting data exists that will require further explanation. LRP has also been implicated as a receptor for alpha2-macroglobulins, which are protease inhibitors present in the plasma. Therefore, it appears that LRP and the alpha2-macroglobulin receptor are the same molecule.
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