Experiments concering the potential carcinogenic effect of isobutyl-2-cyanoacrylate in periodontology and oral surgery
Ribeiro, Sebastiao Alves
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The question of a potential carcinogenic effect of isobutyl-2-cyanoacrylate, utilized as a hemostatic agent and tissue adhesive, was investigated in a long term study. Long-Evans hooded rats were subjected to experimental gingivectomy or extraction procedures; cyanoacrylate monomer was applied post-surgically as an aerosol or wet dressing with suitable controls employed. Two hundred and fifty animals, including controls, survived for examination sixteen to twenty-five months post-operatively, and form the basis for the hematologic and histopathologic observations. Blood studies were essentially normal compared to baseline data. There was no indication of a polymer residuum at superficial or deep application sites, nor was evidence found to substantiate a local neoplastic effect of applied isobutyl-2-cyanoacrylate.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact email@example.com.Thesis (D.Sc.D.)--Boston University School of Graduate Dentistry (Oral biology and pathology), 1976.Includes bibliography.
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