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dc.contributor.authorGraber, Ted G.en_US
dc.contributor.authorFandrey, Katie R.en_US
dc.contributor.authorThompson, LaDora V.en_US
dc.coverage.spatialSwitzerlanden_US
dc.date2019-04-16
dc.date.accessioned2020-05-14T19:38:55Z
dc.date.available2020-05-14T19:38:55Z
dc.date.issued2019-04
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31076998
dc.identifier.citationTed G Graber, Katie R Fandrey, LaDora V Thompson. 2019. "Novel individualized power training protocol preserves physical function in adult and older mice." Geroscience, Volume 41, Issue 2, pp. 165 - 183. https://doi.org/10.1007/s11357-019-00069-z
dc.identifier.issn2509-2723
dc.identifier.urihttps://hdl.handle.net/2144/40887
dc.description.abstractSarcopenia, the age-related loss of muscle mass and strength, contributes to frailty, functional decline, and reduced quality of life in older adults. Exercise is a recognized therapy for sarcopenia and muscle dysfunction, though not a cure. Muscle power declines at an increased rate compared to force, and force output declines earlier than mass. Thus, there is a need for research of exercise focusing on improving power output and functionality in older adults. Our primary purpose was proof-of-concept that a novel individualized power exercise modality would induce positive adaptations in adult mice, before the exercise program was applied to an aged cohort. We hypothesized that after following our protocol, both adult and older mice would show improved function, though there would be evidence of anabolic resistance in the older mice. Male C57BL/6 mice (12 months of age at study conclusion) were randomized into control (n = 9) and exercise (n = 6) groups. The trained group used progressive resistance (with a weighted harness) and intensity (~ 4-10 rpm) on a custom motorized running wheel. The mice trained similarly to a human workout regimen (4-5 sets/session, 3 sessions/week, for 12 weeks). We determined significant (p < 0.05) positive adaptations post-intervention, including: neuromuscular function (rotarod), strength/endurance (inverted cling grip test), training physiology (force/power output per session), muscle size (soleus mass), and power/velocity of contraction (in vitro physiology). Secondly, we trained a cohort of older male mice (28 months old at conclusion): control (n = 12) and exercised (n = 8). While the older exercised mice did preserve function and gain benefits, they also demonstrated evidence of anabolic resistance.en_US
dc.description.sponsorshipF31 AG044108 - NIA NIH HHS; R01 AG017768 - NIA NIH HHS; TL1 TR001440 - Institute for Translational Sciences, University of Texas Medical Branchen_US
dc.format.extentp. 165 - 183en_US
dc.languageeng
dc.language.isoen_US
dc.publisherSpringer Nature Switzerland AGen_US
dc.relation.ispartofGeroscience
dc.subjectExerciseen_US
dc.subjectMiceen_US
dc.subjectMuscleen_US
dc.subjectPoweren_US
dc.subjectSarcopeniaen_US
dc.subjectAdaptation, physiologicalen_US
dc.subjectAdulten_US
dc.subjectAge factorsen_US
dc.subjectAgeden_US
dc.subjectAgingen_US
dc.subjectAnimalsen_US
dc.subjectDisease models, animalen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiceen_US
dc.subjectMice, inbred C57BLen_US
dc.subjectMuscle strengthen_US
dc.subjectPhysical conditioning, animalen_US
dc.subjectRandom allocationen_US
dc.subjectReference valuesen_US
dc.subjectResistance trainingen_US
dc.subjectRisk factorsen_US
dc.titleNovel individualized power training protocol preserves physical function in adult and older miceen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1007/s11357-019-00069-z
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv475330


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